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However the shrubs contain so minor on the compound that pharmacologists are already struggling to study its medicinal apps. Now, a team for the Scripps Research Institute in Jupiter, Florida, has made conolidine inside the lab from simple commencing resources, and found that it has analgesic effects. The scientists describe their findings in a pap

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2.two]decane core and defining the geometry on the exocyclic double bond. The activation energies of formation in the vinyl-gold intermediates were calculated and revealed a silyl enol ether with an unprotected indole moiety as an appropriate precursor to the Toste cyclization. This 6-stage synthesis didn't entail any nonstrategic redox manipulatio